Original Reports: Cancer Potential Differences in Breast Cancer Risk Factors Based on Cyp1a1 Mspi
نویسنده
چکیده
Objectives: Recent studies show that an MspI polymorphism in the 39-noncoding region of the CYP1A1 gene is associated with breast cancer in African-American women but not in Caucasian women. In addition, an African-American-specific (AAS) polymorphism is located in intron 7 of this gene. We hypothesized that the AAS polymorphism may partially account for this race-specific association and that different environmental risk factor profiles are a function of genotype status. We studied both CYP1A1 polymorphisms to determine if African-American women with these variants have breast cancer risk factor profiles that are different from those of other African-American women.
منابع مشابه
A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women.
We examined the role of CYP1A1 polymorphisms as potential molecular markers of breast cancer susceptibility in Caucasian and African-American women. The case-control study involved 51 women with breast cancer and 269 female controls. In African-Americans, the frequency of the homozygous MspI polymorphism was 3.5% in controls and 19% in breast cancer cases. The odds ratio of breast cancer with t...
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BACKGROUND Cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family, which is a key enzyme in the metabolism of many endogenous substrates and exogenous carcinogens. To date, many studies have examined the association between CYP1A1 MspI and Ile462Val polymorphisms and cancer risk in various populations, but their results have been conflicting rather than consistent. METHODS To assess this...
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